Drug interactions
Desipramine + Metoclopramide
Severity: Moderate
Desipramine and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desipramine is a CYP2D6 substrate with noradrenergic activity, and metoclopramide is a dopamine antagonist also metabolized by CYP2D6. Combined use may increase extrapyramidal effects, sedation and risk of serotonergic or neuroleptic-type reactions, and anticholinergic effects may oppose metoclopramide's prokinetic action.
What this interaction means in plain words
Desipramine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desipramine belongs to Central Nervous System; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive central nervous system effects and possible competition at CYP2D6.
What to do
Monitor for tremor, rigidity, akathisia, agitation and sedation. Consider an alternative antiemetic if movement symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Desipramine with Metoclopramide?
MediHelp rates the interaction as moderate. Desipramine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desipramine is a CYP2D6 substrate with noradrenergic activity, and metoclopramide is a dopamine antagonist also metabolized by CYP2D6. Combined use may increase extrapyramidal effects, sedation and risk of serotonergic or neuroleptic-type reactions, and anticholinergic effects may oppose metoclopramide's prokinetic action.
How serious is the interaction between Desipramine and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tremor, rigidity, akathisia, agitation and sedation. Consider an alternative antiemetic if movement symptoms appear.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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