Drug interactions
Desloratadine + Levoketoconazole
Severity: Minor
Desloratadine and Levoketoconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole raised desloratadine concentrations modestly in pharmacokinetic studies without notable clinical consequences. Levoketoconazole is expected to behave similarly, though levoketoconazole itself prolongs QT, which is a separate concern.
What this interaction means in plain words
Desloratadine and Levoketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desloratadine belongs to Respiratory; Levoketoconazole belongs to Endocrine.
Why it happens
Inhibition of P-glycoprotein and metabolic clearance of desloratadine by levoketoconazole.
What to do
No dose change is generally needed for desloratadine. Monitor for increased antihistamine effects and follow routine QT monitoring for levoketoconazole.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desloratadine
- Desloratadine + Erdafitinib Moderate
- Desloratadine + Isocarboxazid Moderate
- Desloratadine + Tranylcypromine Moderate
- Desloratadine + Zuranolone Moderate
- Amifampridine + Desloratadine Minor
- Berotralstat + Desloratadine Minor
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Desloratadine with Levoketoconazole?
MediHelp rates the interaction as minor. Desloratadine and Levoketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ketoconazole raised desloratadine concentrations modestly in pharmacokinetic studies without notable clinical consequences. Levoketoconazole is expected to behave similarly, though levoketoconazole itself prolongs QT, which is a separate concern.
How serious is the interaction between Desloratadine and Levoketoconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed for desloratadine. Monitor for increased antihistamine effects and follow routine QT monitoring for levoketoconazole.
What other medicines interact with Desloratadine?
MediHelp also lists interactions of Desloratadine with, for example, Erdafitinib, Isocarboxazid, Tranylcypromine. The full list is on the Desloratadine page.
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