Drug interactions
Deutetrabenazine + Leuprolide
Severity: Moderate
Deutetrabenazine and Leuprolide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deutetrabenazine has little QT effect at recommended doses, but the risk can rise with additional QT-prolonging drugs such as leuprolide. The combination may matter mainly in patients with bradycardia, electrolyte disturbances or congenital long QT.
What this interaction means in plain words
Deutetrabenazine and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deutetrabenazine belongs to Central Nervous System; Leuprolide belongs to Endocrine.
Why it happens
Additive pharmacodynamic QT prolongation, with a modest contribution from deutetrabenazine.
What to do
Check ECG and correct potassium and magnesium in patients with risk factors. Avoid the combination in congenital long QT syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leuprolide
- Leuprolide + Pimozide Contraindicated
- Leuprolide + Thioridazine Contraindicated
- Amisulpride + Leuprolide Major
- Arsenic trioxide + Leuprolide Major
- Artemether / lumefantrine + Leuprolide Major
- Disopyramide + Leuprolide Major
Other interactions of Deutetrabenazine
- Deutetrabenazine + Isocarboxazid Contraindicated
- Deutetrabenazine + Linezolid Contraindicated
- Deutetrabenazine + Phenelzine Contraindicated
- Deutetrabenazine + Rasagiline Contraindicated
- Deutetrabenazine + Safinamide Contraindicated
- Deutetrabenazine + Selegiline Contraindicated
Frequently asked questions
Can I take Deutetrabenazine with Leuprolide?
MediHelp rates the interaction as moderate. Deutetrabenazine and Leuprolide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deutetrabenazine has little QT effect at recommended doses, but the risk can rise with additional QT-prolonging drugs such as leuprolide. The combination may matter mainly in patients with bradycardia, electrolyte disturbances or congenital long QT.
How serious is the interaction between Deutetrabenazine and Leuprolide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct potassium and magnesium in patients with risk factors. Avoid the combination in congenital long QT syndrome.
What other medicines interact with Leuprolide?
MediHelp also lists interactions of Leuprolide with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Leuprolide page.
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