Drug interactions
Dexamethasone-neomycin-polymyxin + Rolapitant
Severity: Minor
Dexamethasone-neomycin-polymyxin and Rolapitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexamethasone is a weak-to-moderate CYP3A4 inducer, and it is unlikely to meaningfully lower rolapitant exposure when given as a topical or ophthalmic product. Systemic exposure from this preparation is minimal.
What this interaction means in plain words
Dexamethasone-neomycin-polymyxin and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Dexamethasone may weakly induce CYP3A4, but systemic exposure from topical use is negligible.
What to do
No action is needed for topical or ocular use. Be aware of possible reduced rolapitant effect only with prolonged high-dose systemic corticosteroids.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Major
- Dexamethasone-neomycin-polymyxin + Lapatinib Major
- Dexamethasone-neomycin-polymyxin + Levofloxacin Major
- Dexamethasone-neomycin-polymyxin + Mifepristone Major
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Major
- Aldesleukin + Dexamethasone-neomycin-polymyxin Moderate
Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Frequently asked questions
Can I take Dexamethasone-neomycin-polymyxin with Rolapitant?
MediHelp rates the interaction as minor. Dexamethasone-neomycin-polymyxin and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexamethasone is a weak-to-moderate CYP3A4 inducer, and it is unlikely to meaningfully lower rolapitant exposure when given as a topical or ophthalmic product. Systemic exposure from this preparation is minimal.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Rolapitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed for topical or ocular use. Be aware of possible reduced rolapitant effect only with prolonged high-dose systemic corticosteroids.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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