Drug interactions
Dexchlorpheniramine + Modafinil
Severity: Minor
Dexchlorpheniramine and Modafinil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexchlorpheniramine is a sedating antihistamine and modafinil promotes wakefulness, so their effects on alertness may partly oppose each other. The net effect on performance is unpredictable.
What this interaction means in plain words
Dexchlorpheniramine and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexchlorpheniramine belongs to Respiratory; Modafinil belongs to Central Nervous System.
Why it happens
Opposing pharmacodynamic effects on CNS arousal; no established pharmacokinetic interaction.
What to do
Monitor for drowsiness and advise caution when driving. Use a non-sedating antihistamine if sedation is troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Modafinil
Other interactions of Dexchlorpheniramine
- Alprazolam + Dexchlorpheniramine Moderate
- Amisulpride + Dexchlorpheniramine Moderate
- Amitriptyline + Dexchlorpheniramine Moderate
- Amobarbital + Dexchlorpheniramine Moderate
- Asenapine + Dexchlorpheniramine Moderate
- Azelastine-fluticasone + Dexchlorpheniramine Moderate
Frequently asked questions
Can I take Dexchlorpheniramine with Modafinil?
MediHelp rates the interaction as minor. Dexchlorpheniramine and Modafinil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexchlorpheniramine is a sedating antihistamine and modafinil promotes wakefulness, so their effects on alertness may partly oppose each other. The net effect on performance is unpredictable.
How serious is the interaction between Dexchlorpheniramine and Modafinil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for drowsiness and advise caution when driving. Use a non-sedating antihistamine if sedation is troublesome.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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