Drug interactions
Dexchlorpheniramine + Sevoflurane
Severity: Minor
Dexchlorpheniramine and Sevoflurane: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexchlorpheniramine is a sedating antihistamine and adds to the CNS depression of sevoflurane. This may prolong recovery and cause anticholinergic effects.
What this interaction means in plain words
Dexchlorpheniramine and Sevoflurane have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexchlorpheniramine belongs to Respiratory; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive CNS depression through H1 receptor antagonism and anesthetic action.
What to do
Titrate sevoflurane to depth-of-anesthesia monitoring and observe recovery. No routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sevoflurane
Other interactions of Dexchlorpheniramine
- Alprazolam + Dexchlorpheniramine Moderate
- Amisulpride + Dexchlorpheniramine Moderate
- Amitriptyline + Dexchlorpheniramine Moderate
- Amobarbital + Dexchlorpheniramine Moderate
- Asenapine + Dexchlorpheniramine Moderate
- Azelastine-fluticasone + Dexchlorpheniramine Moderate
Frequently asked questions
Can I take Dexchlorpheniramine with Sevoflurane?
MediHelp rates the interaction as minor. Dexchlorpheniramine and Sevoflurane have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexchlorpheniramine is a sedating antihistamine and adds to the CNS depression of sevoflurane. This may prolong recovery and cause anticholinergic effects.
How serious is the interaction between Dexchlorpheniramine and Sevoflurane?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate sevoflurane to depth-of-anesthesia monitoring and observe recovery. No routine dose change is needed.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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