Drug interactions
Dexlansoprazole + Liothyronine
Severity: Minor
Dexlansoprazole and Liothyronine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Acid suppression with dexlansoprazole may modestly reduce absorption of oral liothyronine, although it is less acid-dependent than levothyroxine. Evidence is inconsistent.
What this interaction means in plain words
Dexlansoprazole and Liothyronine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexlansoprazole belongs to Gastrointestinal Tract; Liothyronine belongs to Endocrine.
Why it happens
Higher gastric pH may reduce dissolution and absorption of oral thyroid hormone.
What to do
Check TSH after starting or stopping dexlansoprazole and adjust the liothyronine dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Liothyronine
- Alogliptin-metformin + Liothyronine Moderate
- Amitriptyline + Liothyronine Moderate
- Amobarbital + Liothyronine Moderate
- Canagliflozin-metformin + Liothyronine Moderate
- Carbamazepine + Liothyronine Moderate
- Carbonyl iron + Liothyronine Moderate
Frequently asked questions
Can I take Dexlansoprazole with Liothyronine?
MediHelp rates the interaction as minor. Dexlansoprazole and Liothyronine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Acid suppression with dexlansoprazole may modestly reduce absorption of oral liothyronine, although it is less acid-dependent than levothyroxine. Evidence is inconsistent.
How serious is the interaction between Dexlansoprazole and Liothyronine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check TSH after starting or stopping dexlansoprazole and adjust the liothyronine dose if needed.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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