Drug interactions
Dexlansoprazole + Lisdexamfetamine
Severity: Minor
Dexlansoprazole and Lisdexamfetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Acid suppression can shift the absorption profile of amphetamine released from lisdexamfetamine, with earlier peak concentrations but little change in overall exposure. Clinical impact is minimal.
What this interaction means in plain words
Dexlansoprazole and Lisdexamfetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexlansoprazole belongs to Gastrointestinal Tract; Lisdexamfetamine belongs to Central Nervous System.
Why it happens
Altered gastric pH changes the rate, but not extent, of amphetamine absorption.
What to do
No dose change is needed; monitor clinical response if the PPI is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Lisdexamfetamine
- Isocarboxazid + Lisdexamfetamine Contraindicated
- Linezolid + Lisdexamfetamine Contraindicated
- Lisdexamfetamine + Phenelzine Contraindicated
- Lisdexamfetamine + Procarbazine Contraindicated
- Lisdexamfetamine + Rasagiline Contraindicated
- Lisdexamfetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Dexlansoprazole with Lisdexamfetamine?
MediHelp rates the interaction as minor. Dexlansoprazole and Lisdexamfetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Acid suppression can shift the absorption profile of amphetamine released from lisdexamfetamine, with earlier peak concentrations but little change in overall exposure. Clinical impact is minimal.
How serious is the interaction between Dexlansoprazole and Lisdexamfetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor clinical response if the PPI is started or stopped.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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