Drug interactions
Dexlansoprazole + Tucatinib
Severity: Minor
Dexlansoprazole and Tucatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib is a strong CYP3A inhibitor and may raise dexlansoprazole exposure. Dexlansoprazole has a wide therapeutic margin, so clinically significant harm is unlikely.
What this interaction means in plain words
Dexlansoprazole and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexlansoprazole belongs to Gastrointestinal Tract; Tucatinib belongs to Oncology.
Why it happens
Inhibition of CYP3A-mediated dexlansoprazole metabolism by tucatinib.
What to do
No dose change is generally required. Monitor for PPI adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Dexlansoprazole with Tucatinib?
MediHelp rates the interaction as minor. Dexlansoprazole and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tucatinib is a strong CYP3A inhibitor and may raise dexlansoprazole exposure. Dexlansoprazole has a wide therapeutic margin, so clinically significant harm is unlikely.
How serious is the interaction between Dexlansoprazole and Tucatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally required. Monitor for PPI adverse effects.
What other medicines interact with Dexlansoprazole?
MediHelp also lists interactions of Dexlansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Dexlansoprazole page.
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