Drug interactions
Dexmedetomidine + Midodrine
Severity: Moderate
Dexmedetomidine and Midodrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midodrine raises blood pressure through alpha-1 agonism and may reflexly slow heart rate, which could add to dexmedetomidine-induced bradycardia. It may also oppose dexmedetomidine hypotension.
What this interaction means in plain words
Dexmedetomidine and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexmedetomidine belongs to Central Nervous System; Midodrine belongs to Miscellaneous.
Why it happens
Opposing blood pressure effects, with additive bradycardia from vasoconstriction-mediated reflex and alpha-2 agonism.
What to do
Monitor heart rate and blood pressure, and adjust doses if bradycardia or unstable pressure occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexmedetomidine
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Dexmedetomidine with Midodrine?
MediHelp rates the interaction as moderate. Dexmedetomidine and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midodrine raises blood pressure through alpha-1 agonism and may reflexly slow heart rate, which could add to dexmedetomidine-induced bradycardia. It may also oppose dexmedetomidine hypotension.
How serious is the interaction between Dexmedetomidine and Midodrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure, and adjust doses if bradycardia or unstable pressure occurs.
What other medicines interact with Dexmedetomidine?
MediHelp also lists interactions of Dexmedetomidine with, for example, Buprenorphine long-acting, Calcium / magnesium / potassium / sodium oxybates, Dextromoramide. The full list is on the Dexmedetomidine page.
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