Drug interactions
Dexmedetomidine + Trazodone
Severity: Moderate
Dexmedetomidine and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, and dexmedetomidine also lowers heart rate and blood pressure. Together they may produce excessive sedation, hypotension or bradycardia.
What this interaction means in plain words
Dexmedetomidine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexmedetomidine belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects, with additive hypotensive effects from alpha-2 agonism and trazodone alpha-1 blockade.
What to do
Monitor sedation level, blood pressure and heart rate, and reduce the dexmedetomidine or trazodone dose if oversedation or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dexmedetomidine and Trazodone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Dexmedetomidine
Frequently asked questions
Can I take Dexmedetomidine with Trazodone?
MediHelp rates the interaction as moderate. Dexmedetomidine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, and dexmedetomidine also lowers heart rate and blood pressure. Together they may produce excessive sedation, hypotension or bradycardia.
How serious is the interaction between Dexmedetomidine and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level, blood pressure and heart rate, and reduce the dexmedetomidine or trazodone dose if oversedation or hypotension occurs.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
