Drug interactions
Dexmedetomidine + Vortioxetine
Severity: Minor
Dexmedetomidine and Vortioxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexmedetomidine is not established as a clinically meaningful CYP2D6 inhibitor, so a relevant rise in vortioxetine levels is unlikely. Additive sedation or bradycardia/hypotension are possible but not well documented with this pair.
What this interaction means in plain words
Dexmedetomidine and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dexmedetomidine belongs to Central Nervous System; Vortioxetine belongs to Central Nervous System.
Why it happens
A weak in vitro CYP2D6 inhibition signal; no firmly established mechanism of clinical interaction.
What to do
No dose adjustment of vortioxetine is needed. Monitor sedation and hemodynamics as usual during dexmedetomidine infusion.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Dexmedetomidine
Frequently asked questions
Can I take Dexmedetomidine with Vortioxetine?
MediHelp rates the interaction as minor. Dexmedetomidine and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexmedetomidine is not established as a clinically meaningful CYP2D6 inhibitor, so a relevant rise in vortioxetine levels is unlikely. Additive sedation or bradycardia/hypotension are possible but not well documented with this pair.
How serious is the interaction between Dexmedetomidine and Vortioxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment of vortioxetine is needed. Monitor sedation and hemodynamics as usual during dexmedetomidine infusion.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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