Drug interactions
Dexmethylphenidate + Fluticasone-salmeterol
Severity: Moderate
Dexmethylphenidate and Fluticasone-salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexmethylphenidate is a stimulant that raises heart rate and blood pressure, and salmeterol can produce tachycardia and palpitations. Using them together may add to cardiovascular stimulation, which matters in patients with hypertension, arrhythmia or ischemic heart disease.
What this interaction means in plain words
Dexmethylphenidate and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexmethylphenidate belongs to Central Nervous System; Fluticasone-salmeterol belongs to Respiratory.
Why it happens
Additive sympathomimetic cardiovascular effects.
What to do
Monitor heart rate and blood pressure, particularly when starting or increasing either drug. Reassess the combination in patients with cardiovascular disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contraindicated
- Fluticasone-salmeterol + Fosamprenavir Contraindicated
- Fluticasone-salmeterol + Indinavir Contraindicated
- Fluticasone-salmeterol + Lopinavir Contraindicated
- Fluticasone-salmeterol + Nelfinavir Contraindicated
Other interactions of Dexmethylphenidate
- Dexmethylphenidate + Isocarboxazid Contraindicated
- Dexmethylphenidate + Linezolid Contraindicated
- Dexmethylphenidate + Phenelzine Contraindicated
- Dexmethylphenidate + Procarbazine Contraindicated
- Dexmethylphenidate + Rasagiline Contraindicated
- Dexmethylphenidate + Safinamide Contraindicated
Frequently asked questions
Can I take Dexmethylphenidate with Fluticasone-salmeterol?
MediHelp rates the interaction as moderate. Dexmethylphenidate and Fluticasone-salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dexmethylphenidate is a stimulant that raises heart rate and blood pressure, and salmeterol can produce tachycardia and palpitations. Using them together may add to cardiovascular stimulation, which matters in patients with hypertension, arrhythmia or ischemic heart disease.
How serious is the interaction between Dexmethylphenidate and Fluticasone-salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure, particularly when starting or increasing either drug. Reassess the combination in patients with cardiovascular disease.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.
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