Drug interactions
DHEA + Guanfacine
Severity: Minor
DHEA and Guanfacine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
DHEA is only a weak, poorly documented CYP3A4 modulator, and its effect on guanfacine is not established. Guanfacine exposure rises substantially with strong CYP3A4 inhibitors, so any increase could mean more bradycardia, hypotension and sedation.
What this interaction means in plain words
DHEA and Guanfacine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
DHEA belongs to Gastrointestinal Tract; Guanfacine belongs to Cardiovascular.
Why it happens
Possible CYP3A4 inhibition by DHEA, which would reduce guanfacine metabolism; this is theoretical.
What to do
Monitor heart rate, blood pressure and sedation if DHEA supplements are started or stopped. Lower the guanfacine dose if adverse effects appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of DHEA
- DHEA + Dihydroergotamine Moderate
- DHEA + Dihydroergotamine intranasal Moderate
- DHEA + Ergotamine Moderate
- DHEA + Pimozide Moderate
- DHEA + Dronedarone Minor
- DHEA + Erythromycin base Minor
Other interactions of Guanfacine
- Clonidine + Guanfacine Major
- Guanfacine + Lofexidine Major
- Aldesleukin + Guanfacine Moderate
- Amiodarone + Guanfacine Moderate
- Amisulpride + Guanfacine Moderate
- Amitriptyline + Guanfacine Moderate
Frequently asked questions
Can I take DHEA with Guanfacine?
MediHelp rates the interaction as minor. DHEA and Guanfacine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. DHEA is only a weak, poorly documented CYP3A4 modulator, and its effect on guanfacine is not established. Guanfacine exposure rises substantially with strong CYP3A4 inhibitors, so any increase could mean more bradycardia, hypotension and sedation.
How serious is the interaction between DHEA and Guanfacine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and sedation if DHEA supplements are started or stopped. Lower the guanfacine dose if adverse effects appear.
What other medicines interact with DHEA?
MediHelp also lists interactions of DHEA with, for example, Dihydroergotamine, Dihydroergotamine intranasal, Ergotamine. The full list is on the DHEA page.
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