Drug interactions
Diclofenac + Teriflunomide
Severity: Minor
Diclofenac and Teriflunomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide may raise diclofenac exposure modestly, though this is not well characterized. Both drugs can affect the liver, so additive hepatic stress is possible.
What this interaction means in plain words
Diclofenac and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diclofenac belongs to Musculoskeletal; Teriflunomide belongs to Central Nervous System.
Why it happens
Teriflunomide inhibits CYP2C8, which contributes a minor pathway to diclofenac hydroxylation; CYP2C9 is the main route.
What to do
No dose change is routinely needed; monitor liver enzymes and for diclofenac adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Diclofenac and Teriflunomide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Teriflunomide
Frequently asked questions
Can I take Diclofenac with Teriflunomide?
MediHelp rates the interaction as minor. Diclofenac and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Teriflunomide may raise diclofenac exposure modestly, though this is not well characterized. Both drugs can affect the liver, so additive hepatic stress is possible.
How serious is the interaction between Diclofenac and Teriflunomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; monitor liver enzymes and for diclofenac adverse effects.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
