Drug interactions
Diclofenac + Ticlopidine
Severity: Moderate
Diclofenac and Ticlopidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticlopidine inhibits several CYP enzymes including CYP2C9, which may modestly raise diclofenac exposure. Ticlopidine also impairs platelet function, so combining it with an NSAID adds to gastrointestinal and other bleeding risk.
What this interaction means in plain words
Diclofenac and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diclofenac belongs to Musculoskeletal; Ticlopidine belongs to Cardiovascular.
Why it happens
CYP2C9 inhibition by ticlopidine reduces diclofenac metabolism, and both drugs impair hemostasis through additive antiplatelet effects.
What to do
Avoid combining where possible; if used together, give the lowest effective diclofenac dose for the shortest time and monitor for GI bleeding, considering gastroprotection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Diclofenac and Ticlopidine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Ticlopidine
Frequently asked questions
Can I take Diclofenac with Ticlopidine?
MediHelp rates the interaction as moderate. Diclofenac and Ticlopidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ticlopidine inhibits several CYP enzymes including CYP2C9, which may modestly raise diclofenac exposure. Ticlopidine also impairs platelet function, so combining it with an NSAID adds to gastrointestinal and other bleeding risk.
How serious is the interaction between Diclofenac and Ticlopidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; if used together, give the lowest effective diclofenac dose for the shortest time and monitor for GI bleeding, considering gastroprotection.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
