Drug interactions
Dicloxacillin + Hydrochlorothiazide-irbesartan
Severity: Minor
Dicloxacillin and Hydrochlorothiazide-irbesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Penicillins and thiazides are both eliminated by renal tubular secretion, so a minor mutual change in clearance is theoretically possible. No clinically meaningful effect is established for dicloxacillin with hydrochlorothiazide.
What this interaction means in plain words
Dicloxacillin and Hydrochlorothiazide-irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dicloxacillin belongs to Anti Bacterial; Hydrochlorothiazide-irbesartan belongs to Cardiovascular.
Why it happens
Possible competition for renal tubular organic anion secretion.
What to do
No specific action is needed beyond routine monitoring of clinical response and renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Other interactions of Dicloxacillin
- Dicloxacillin + Phenindione Major
- Atogepant + Dicloxacillin Moderate
- Axitinib + Dicloxacillin Moderate
- Bcg vaccine live + Dicloxacillin Moderate
- Cholera vaccine + Dicloxacillin Moderate
- Demeclocycline + Dicloxacillin Moderate
Frequently asked questions
Can I take Dicloxacillin with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as minor. Dicloxacillin and Hydrochlorothiazide-irbesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Penicillins and thiazides are both eliminated by renal tubular secretion, so a minor mutual change in clearance is theoretically possible. No clinically meaningful effect is established for dicloxacillin with hydrochlorothiazide.
How serious is the interaction between Dicloxacillin and Hydrochlorothiazide-irbesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond routine monitoring of clinical response and renal function.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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