Drug interactions
Dicyclomine + Hyoscyamine
Severity: Moderate
Dicyclomine and Hyoscyamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are antimuscarinic antispasmodics, so using them together duplicates therapy and adds to anticholinergic adverse effects. Dry mouth, constipation, urinary retention, tachycardia and confusion become more likely.
What this interaction means in plain words
Dicyclomine and Hyoscyamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicyclomine belongs to Respiratory; Hyoscyamine belongs to Genitourinary.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Avoid concurrent use of two antispasmodic anticholinergics; if unavoidable, use the lowest doses and monitor for urinary retention and constipation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Other interactions of Hyoscyamine
- Amantadine + Hyoscyamine Moderate
- Amitriptyline + Hyoscyamine Moderate
- Aripiprazole + Hyoscyamine Moderate
- Atropine + Hyoscyamine Moderate
- Benztropine + Hyoscyamine Moderate
- Bethanechol + Hyoscyamine Moderate
Frequently asked questions
Can I take Dicyclomine with Hyoscyamine?
MediHelp rates the interaction as moderate. Dicyclomine and Hyoscyamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are antimuscarinic antispasmodics, so using them together duplicates therapy and adds to anticholinergic adverse effects. Dry mouth, constipation, urinary retention, tachycardia and confusion become more likely.
How serious is the interaction between Dicyclomine and Hyoscyamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two antispasmodic anticholinergics; if unavoidable, use the lowest doses and monitor for urinary retention and constipation.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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