Drug interactions
Dicyclomine + Tiotropium-olodaterol
Severity: Moderate
Dicyclomine and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dicyclomine is an antimuscarinic antispasmodic, and combining it with tiotropium increases anticholinergic burden. This may cause more dry mouth, constipation, urinary retention, tachycardia and blurred vision.
What this interaction means in plain words
Dicyclomine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicyclomine belongs to Respiratory; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive antimuscarinic receptor blockade.
What to do
Monitor for anticholinergic adverse effects, particularly in older patients or those with glaucoma or urinary retention. Reduce or stop dicyclomine if symptoms emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Frequently asked questions
Can I take Dicyclomine with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Dicyclomine and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dicyclomine is an antimuscarinic antispasmodic, and combining it with tiotropium increases anticholinergic burden. This may cause more dry mouth, constipation, urinary retention, tachycardia and blurred vision.
How serious is the interaction between Dicyclomine and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects, particularly in older patients or those with glaucoma or urinary retention. Reduce or stop dicyclomine if symptoms emerge.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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