Drug interactions
Dicyclomine + Trazodone
Severity: Minor
Dicyclomine and Trazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trazodone has weak antimuscarinic activity, so additive anticholinergic effects with dicyclomine are possible but usually mild. Sedation and dizziness may also add up in some patients.
What this interaction means in plain words
Dicyclomine and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dicyclomine belongs to Respiratory; Trazodone belongs to Central Nervous System.
Why it happens
Weak additive muscarinic blockade plus additive sedation.
What to do
Monitor older patients for dry mouth, constipation, urinary retention and confusion. No dose change is normally required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Dicyclomine with Trazodone?
MediHelp rates the interaction as minor. Dicyclomine and Trazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trazodone has weak antimuscarinic activity, so additive anticholinergic effects with dicyclomine are possible but usually mild. Sedation and dizziness may also add up in some patients.
How serious is the interaction between Dicyclomine and Trazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor older patients for dry mouth, constipation, urinary retention and confusion. No dose change is normally required.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
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