Drug interactions
Dicyclomine + Trimipramine
Severity: Moderate
Dicyclomine and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine is a tricyclic antidepressant with substantial antimuscarinic activity, so adding dicyclomine increases the risk of dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion. Severe cases may produce ileus or delirium.
What this interaction means in plain words
Dicyclomine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dicyclomine belongs to Respiratory; Trimipramine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects at peripheral and central muscarinic receptors.
What to do
Monitor for anticholinergic toxicity and reduce or discontinue dicyclomine if bothersome effects appear. Use particular care in older patients and those with glaucoma or prostatic hypertrophy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dicyclomine and Trimipramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dicyclomine
- Clozapine + Dicyclomine Major
- Dicyclomine + Henbane Major
- Dicyclomine + Imipramine Major
- Dicyclomine + Pramlintide Major
- Abobotulinumtoxina + Dicyclomine Moderate
- Aclidinium + Dicyclomine Moderate
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Dicyclomine with Trimipramine?
MediHelp rates the interaction as moderate. Dicyclomine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimipramine is a tricyclic antidepressant with substantial antimuscarinic activity, so adding dicyclomine increases the risk of dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion. Severe cases may produce ileus or delirium.
How serious is the interaction between Dicyclomine and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and reduce or discontinue dicyclomine if bothersome effects appear. Use particular care in older patients and those with glaucoma or prostatic hypertrophy.
What other medicines interact with Dicyclomine?
MediHelp also lists interactions of Dicyclomine with, for example, Clozapine, Henbane, Imipramine. The full list is on the Dicyclomine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
