Drug interactions
Difelikefalin + Risperidone
Severity: Moderate
Difelikefalin and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin is a peripherally restricted kappa-opioid agonist that can cause somnolence and dizziness. Together with risperidone, sedation and dizziness may be more pronounced, especially in dialysis patients.
What this interaction means in plain words
Difelikefalin and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Difelikefalin belongs to Dermatology; Risperidone belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for somnolence, dizziness and falls. Reduce doses if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Difelikefalin with Risperidone?
MediHelp rates the interaction as moderate. Difelikefalin and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difelikefalin is a peripherally restricted kappa-opioid agonist that can cause somnolence and dizziness. Together with risperidone, sedation and dizziness may be more pronounced, especially in dialysis patients.
How serious is the interaction between Difelikefalin and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for somnolence, dizziness and falls. Reduce doses if excessive sedation occurs.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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