Drug interactions
Difelikefalin + Sevoflurane
Severity: Minor
Difelikefalin and Sevoflurane: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin is a peripherally restricted kappa-opioid agonist that can cause somnolence and dizziness, and it may add to sevoflurane sedation. The effect is expected to be modest.
What this interaction means in plain words
Difelikefalin and Sevoflurane have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Difelikefalin belongs to Dermatology; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive CNS depression; difelikefalin acts mainly peripherally but can produce some central effects.
What to do
Titrate sevoflurane to depth-of-anesthesia monitoring and observe the patient during recovery.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sevoflurane
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Difelikefalin with Sevoflurane?
MediHelp rates the interaction as minor. Difelikefalin and Sevoflurane have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Difelikefalin is a peripherally restricted kappa-opioid agonist that can cause somnolence and dizziness, and it may add to sevoflurane sedation. The effect is expected to be modest.
How serious is the interaction between Difelikefalin and Sevoflurane?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate sevoflurane to depth-of-anesthesia monitoring and observe the patient during recovery.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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