Drug interactions
Difelikefalin + Vortioxetine
Severity: Minor
Difelikefalin and Vortioxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin, a kappa opioid agonist given to hemodialysis patients, can cause somnolence and dizziness. Vortioxetine may add to these effects, and combined use could increase sedation and fall risk.
What this interaction means in plain words
Difelikefalin and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Difelikefalin belongs to Dermatology; Vortioxetine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for excess drowsiness, dizziness and falls, especially in older dialysis patients. Reduce doses or review therapy if sedation becomes problematic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Difelikefalin with Vortioxetine?
MediHelp rates the interaction as minor. Difelikefalin and Vortioxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Difelikefalin, a kappa opioid agonist given to hemodialysis patients, can cause somnolence and dizziness. Vortioxetine may add to these effects, and combined use could increase sedation and fall risk.
How serious is the interaction between Difelikefalin and Vortioxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess drowsiness, dizziness and falls, especially in older dialysis patients. Reduce doses or review therapy if sedation becomes problematic.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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