Drug interactions
Digoxin + Eliglustat
Severity: Moderate
Digoxin and Eliglustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits P-glycoprotein and increases digoxin exposure. Digoxin toxicity, including arrhythmia and gastrointestinal symptoms, may occur if the dose is not reduced.
What this interaction means in plain words
Digoxin and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Eliglustat belongs to Miscellaneous.
Why it happens
Eliglustat inhibits P-glycoprotein, decreasing digoxin efflux and elimination.
What to do
Measure digoxin concentration before starting eliglustat and lower the digoxin dose as labeled. Continue monitoring levels and clinical status.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Digoxin with Eliglustat?
MediHelp rates the interaction as moderate. Digoxin and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat inhibits P-glycoprotein and increases digoxin exposure. Digoxin toxicity, including arrhythmia and gastrointestinal symptoms, may occur if the dose is not reduced.
How serious is the interaction between Digoxin and Eliglustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure digoxin concentration before starting eliglustat and lower the digoxin dose as labeled. Continue monitoring levels and clinical status.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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