Drug interactions
Digoxin + Eluxadoline
Severity: Minor
Digoxin and Eluxadoline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
There is no established mechanism by which digoxin raises eluxadoline levels, since digoxin is not an OATP1B1 inhibitor. Eluxadoline may weakly affect P-gp substrates, but no meaningful interaction is documented.
What this interaction means in plain words
Digoxin and Eluxadoline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Eluxadoline belongs to Gastrointestinal Tract.
Why it happens
No established mechanism; any effect would be theoretical transporter-related.
What to do
No dose adjustment is needed. Monitor for digoxin toxicity if clinical concern arises.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Eluxadoline
Frequently asked questions
Can I take Digoxin with Eluxadoline?
MediHelp rates the interaction as minor. Digoxin and Eluxadoline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. There is no established mechanism by which digoxin raises eluxadoline levels, since digoxin is not an OATP1B1 inhibitor. Eluxadoline may weakly affect P-gp substrates, but no meaningful interaction is documented.
How serious is the interaction between Digoxin and Eluxadoline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for digoxin toxicity if clinical concern arises.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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