Drug interactions
Digoxin + Esmolol
Severity: Moderate
Digoxin and Esmolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both digoxin and esmolol slow AV nodal conduction, so together they can cause bradycardia and heart block. Esmolol has also been reported to modestly raise digoxin concentrations.
What this interaction means in plain words
Digoxin and Esmolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Esmolol belongs to Cardiovascular.
Why it happens
Additive slowing of AV nodal conduction, with a possible small pharmacokinetic increase in digoxin levels.
What to do
Monitor heart rate, ECG and digoxin concentration when esmolol is started in digoxin-treated patients. Reduce or stop esmolol if significant bradycardia or AV block occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Esmolol?
MediHelp rates the interaction as moderate. Digoxin and Esmolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both digoxin and esmolol slow AV nodal conduction, so together they can cause bradycardia and heart block. Esmolol has also been reported to modestly raise digoxin concentrations.
How serious is the interaction between Digoxin and Esmolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG and digoxin concentration when esmolol is started in digoxin-treated patients. Reduce or stop esmolol if significant bradycardia or AV block occurs.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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