Drug interactions
Digoxin + Ethacrynic acid
Severity: Moderate
Digoxin and Ethacrynic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics such as ethacrynic acid cause potassium and magnesium depletion, which increases myocardial sensitivity to digoxin. This can precipitate arrhythmias even at normal digoxin levels.
What this interaction means in plain words
Digoxin and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Ethacrynic acid belongs to Cardiovascular.
Why it happens
Diuretic-induced hypokalemia and hypomagnesemia enhance digoxin binding to Na+/K+-ATPase and its proarrhythmic effect.
What to do
Monitor serum potassium and magnesium regularly and replace losses. Consider potassium-sparing therapy and monitor for digoxin toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Digoxin with Ethacrynic acid?
MediHelp rates the interaction as moderate. Digoxin and Ethacrynic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics such as ethacrynic acid cause potassium and magnesium depletion, which increases myocardial sensitivity to digoxin. This can precipitate arrhythmias even at normal digoxin levels.
How serious is the interaction between Digoxin and Ethacrynic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium regularly and replace losses. Consider potassium-sparing therapy and monitor for digoxin toxicity.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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