Drug interactions
Digoxin + Ethinyl estradiol-drospirenone
Severity: Minor
Digoxin and Ethinyl estradiol-drospirenone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Digoxin inhibits the Na/K-ATPase pump and in toxicity can cause hyperkalemia, while drospirenone can also raise potassium. Potassium shifts alter digoxin sensitivity, so potassium disturbances in patients on digoxin carry arrhythmia risk, although the clinical effect from this combination is usually small.
What this interaction means in plain words
Digoxin and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Ethinyl estradiol-drospirenone belongs to Endocrine.
Why it happens
Additive tendency to raise potassium through aldosterone antagonism (drospirenone) and Na/K-ATPase inhibition (digoxin).
What to do
Check serum potassium and renal function when starting drospirenone in patients on digoxin, particularly those with renal impairment. Monitor digoxin levels if clinically indicated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as minor. Digoxin and Ethinyl estradiol-drospirenone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Digoxin inhibits the Na/K-ATPase pump and in toxicity can cause hyperkalemia, while drospirenone can also raise potassium. Potassium shifts alter digoxin sensitivity, so potassium disturbances in patients on digoxin carry arrhythmia risk, although the clinical effect from this combination is usually small.
How serious is the interaction between Digoxin and Ethinyl estradiol-drospirenone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and renal function when starting drospirenone in patients on digoxin, particularly those with renal impairment. Monitor digoxin levels if clinically indicated.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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