Drug interactions
Digoxin + Etravirine
Severity: Moderate
Digoxin and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine modestly increases digoxin exposure, which may raise the risk of toxicity in some patients. Digoxin's narrow therapeutic index makes this relevant.
What this interaction means in plain words
Digoxin and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Etravirine belongs to Anti Virals.
Why it happens
Etravirine inhibits P-glycoprotein, increasing digoxin absorption and decreasing its clearance.
What to do
Monitor serum digoxin concentrations and start digoxin at the lowest dose. Titrate based on levels and clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Digoxin with Etravirine?
MediHelp rates the interaction as moderate. Digoxin and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine modestly increases digoxin exposure, which may raise the risk of toxicity in some patients. Digoxin's narrow therapeutic index makes this relevant.
How serious is the interaction between Digoxin and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin concentrations and start digoxin at the lowest dose. Titrate based on levels and clinical response.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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