Drug interactions
Digoxin + Flibanserin
Severity: Moderate
Digoxin and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flibanserin inhibits intestinal P-glycoprotein and can increase exposure to digoxin, a narrow therapeutic index P-gp substrate. Higher digoxin levels may lead to nausea, arrhythmias and other signs of digoxin toxicity.
What this interaction means in plain words
Digoxin and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Flibanserin belongs to Genitourinary.
Why it happens
Flibanserin inhibits P-glycoprotein efflux, increasing digoxin absorption and reducing its clearance.
What to do
Monitor serum digoxin concentrations and clinical signs of toxicity when starting or stopping flibanserin. Reduce the digoxin dose if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Flibanserin?
MediHelp rates the interaction as moderate. Digoxin and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flibanserin inhibits intestinal P-glycoprotein and can increase exposure to digoxin, a narrow therapeutic index P-gp substrate. Higher digoxin levels may lead to nausea, arrhythmias and other signs of digoxin toxicity.
How serious is the interaction between Digoxin and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin concentrations and clinical signs of toxicity when starting or stopping flibanserin. Reduce the digoxin dose if levels rise.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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