Drug interactions
Digoxin + Gemifloxacin
Severity: Moderate
Digoxin and Gemifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics may raise digoxin levels in a minority of patients by reducing gut bacteria that inactivate digoxin. This can lead to digoxin toxicity such as nausea, arrhythmia or visual changes. The effect is variable and unpredictable.
What this interaction means in plain words
Digoxin and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Gemifloxacin belongs to Anti Bacterial.
Why it happens
Reduced intestinal Eggerthella lenta metabolism of digoxin increases its absorption and bioavailability.
What to do
Monitor for signs of digoxin toxicity and check digoxin level and renal function if symptoms occur. Adjust the digoxin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Gemifloxacin?
MediHelp rates the interaction as moderate. Digoxin and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antibiotics may raise digoxin levels in a minority of patients by reducing gut bacteria that inactivate digoxin. This can lead to digoxin toxicity such as nausea, arrhythmia or visual changes. The effect is variable and unpredictable.
How serious is the interaction between Digoxin and Gemifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of digoxin toxicity and check digoxin level and renal function if symptoms occur. Adjust the digoxin dose as needed.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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