Drug interactions
Digoxin + Gilteritinib
Severity: Moderate
Digoxin and Gilteritinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gilteritinib may inhibit P-glycoprotein and could increase digoxin concentrations. Digoxin has a narrow therapeutic index, so toxicity such as arrhythmia or nausea is possible.
What this interaction means in plain words
Digoxin and Gilteritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Gilteritinib belongs to Oncology.
Why it happens
Inhibition of intestinal and renal P-gp by gilteritinib may reduce digoxin efflux and elimination.
What to do
Monitor serum digoxin concentrations and ECG when starting or stopping gilteritinib. Reduce the digoxin dose if levels or toxicity signs rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gilteritinib
- Gilteritinib + Pimozide Contraindicated
- Amiodarone + Gilteritinib Major
- Amisulpride + Gilteritinib Major
- Amitriptyline + Gilteritinib Major
- Anagrelide + Gilteritinib Major
- Apalutamide + Gilteritinib Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Gilteritinib?
MediHelp rates the interaction as moderate. Digoxin and Gilteritinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gilteritinib may inhibit P-glycoprotein and could increase digoxin concentrations. Digoxin has a narrow therapeutic index, so toxicity such as arrhythmia or nausea is possible.
How serious is the interaction between Digoxin and Gilteritinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin concentrations and ECG when starting or stopping gilteritinib. Reduce the digoxin dose if levels or toxicity signs rise.
What other medicines interact with Gilteritinib?
MediHelp also lists interactions of Gilteritinib with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Gilteritinib page.
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