Drug interactions
Digoxin + Labetalol
Severity: Moderate
Digoxin and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs slow AV nodal conduction, so combined use can cause bradycardia and heart block. Digoxin toxicity is not directly increased, but the conduction effects are additive.
What this interaction means in plain words
Digoxin and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Labetalol belongs to Cardiovascular.
Why it happens
Additive depression of AV nodal conduction from beta-blockade and enhanced vagal tone from digoxin.
What to do
Monitor heart rate and ECG, especially in older patients or those with conduction disease. Reduce doses if symptomatic bradycardia or AV block occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Labetalol?
MediHelp rates the interaction as moderate. Digoxin and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs slow AV nodal conduction, so combined use can cause bradycardia and heart block. Digoxin toxicity is not directly increased, but the conduction effects are additive.
How serious is the interaction between Digoxin and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG, especially in older patients or those with conduction disease. Reduce doses if symptomatic bradycardia or AV block occurs.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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