Drug interactions
Digoxin + Lasmiditan
Severity: Moderate
Digoxin and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits P-glycoprotein in vitro and may increase digoxin exposure. Higher digoxin levels could lead to toxicity, and lasmiditan can also slow heart rate.
What this interaction means in plain words
Digoxin and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Lasmiditan belongs to Central Nervous System.
Why it happens
Lasmiditan inhibits intestinal P-glycoprotein, increasing digoxin absorption.
What to do
Avoid giving lasmiditan to patients on digoxin where possible, or monitor digoxin levels and heart rate. Do not use more than one lasmiditan dose in 24 hours.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Digoxin with Lasmiditan?
MediHelp rates the interaction as moderate. Digoxin and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan inhibits P-glycoprotein in vitro and may increase digoxin exposure. Higher digoxin levels could lead to toxicity, and lasmiditan can also slow heart rate.
How serious is the interaction between Digoxin and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving lasmiditan to patients on digoxin where possible, or monitor digoxin levels and heart rate. Do not use more than one lasmiditan dose in 24 hours.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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