Drug interactions
Digoxin + Liposomal doxorubicin
Severity: Moderate
Digoxin and Liposomal doxorubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytotoxic chemotherapy that damages the gut mucosa can reduce absorption of oral digoxin tablets, lowering serum levels and effect. This is documented with some cytotoxic regimens and is less established for liposomal doxorubicin specifically.
What this interaction means in plain words
Digoxin and Liposomal doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Liposomal doxorubicin belongs to Oncology.
Why it happens
Possible reduced intestinal absorption of digoxin from chemotherapy-induced mucosal damage.
What to do
Monitor serum digoxin levels and heart rate or rhythm control. Consider digoxin capsules or an alternative route if levels fall.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Liposomal doxorubicin?
MediHelp rates the interaction as moderate. Digoxin and Liposomal doxorubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytotoxic chemotherapy that damages the gut mucosa can reduce absorption of oral digoxin tablets, lowering serum levels and effect. This is documented with some cytotoxic regimens and is less established for liposomal doxorubicin specifically.
How serious is the interaction between Digoxin and Liposomal doxorubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin levels and heart rate or rhythm control. Consider digoxin capsules or an alternative route if levels fall.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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