Drug interactions
Digoxin + Lomitapide
Severity: Moderate
Digoxin and Lomitapide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lomitapide inhibits P-glycoprotein and may increase systemic digoxin exposure. This could raise the risk of digoxin toxicity in patients on stable doses.
What this interaction means in plain words
Digoxin and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Lomitapide belongs to Cardiovascular.
Why it happens
Lomitapide inhibits P-glycoprotein efflux transport, increasing digoxin absorption and reducing elimination.
What to do
Check digoxin levels after starting lomitapide and consider a lower digoxin dose. Monitor for symptoms and ECG changes of toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Lomitapide
- Aprepitant + Lomitapide Contraindicated
- Clarithromycin + Lomitapide Contraindicated
- Crizotinib + Lomitapide Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Efavirenz + Lomitapide Contraindicated
- Ensitrelvir + Lomitapide Contraindicated
Frequently asked questions
Can I take Digoxin with Lomitapide?
MediHelp rates the interaction as moderate. Digoxin and Lomitapide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lomitapide inhibits P-glycoprotein and may increase systemic digoxin exposure. This could raise the risk of digoxin toxicity in patients on stable doses.
How serious is the interaction between Digoxin and Lomitapide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check digoxin levels after starting lomitapide and consider a lower digoxin dose. Monitor for symptoms and ECG changes of toxicity.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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