Drug interactions
Digoxin + Lornoxicam
Severity: Moderate
Digoxin and Lornoxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal function and raise potassium, and some have been reported to raise digoxin concentrations. This may increase the risk of digoxin toxicity, particularly in older patients or those with renal impairment.
What this interaction means in plain words
Digoxin and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Lornoxicam belongs to Musculoskeletal.
Why it happens
NSAID-related reduction in renal prostaglandin-dependent perfusion and glomerular filtration decreases digoxin clearance.
What to do
Monitor renal function, potassium and digoxin levels when lornoxicam is used, and prefer the shortest course possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Lornoxicam
Frequently asked questions
Can I take Digoxin with Lornoxicam?
MediHelp rates the interaction as moderate. Digoxin and Lornoxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal function and raise potassium, and some have been reported to raise digoxin concentrations. This may increase the risk of digoxin toxicity, particularly in older patients or those with renal impairment.
How serious is the interaction between Digoxin and Lornoxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function, potassium and digoxin levels when lornoxicam is used, and prefer the shortest course possible.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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