Drug interactions
Digoxin + Losartan
Severity: Minor
Digoxin and Losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Losartan does not meaningfully alter digoxin pharmacokinetics, and digoxin does not raise potassium. However, changes in renal function or potassium with losartan can affect digoxin toxicity risk.
What this interaction means in plain words
Digoxin and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Losartan belongs to Cardiovascular.
Why it happens
No direct interaction; indirect effects through electrolyte and renal function changes.
What to do
Monitor potassium and renal function periodically, and check digoxin level if toxicity is suspected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Losartan?
MediHelp rates the interaction as minor. Digoxin and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Losartan does not meaningfully alter digoxin pharmacokinetics, and digoxin does not raise potassium. However, changes in renal function or potassium with losartan can affect digoxin toxicity risk.
How serious is the interaction between Digoxin and Losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium and renal function periodically, and check digoxin level if toxicity is suspected.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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