Drug interactions
Digoxin + Magnesium hydroxide
Severity: Moderate
Digoxin and Magnesium hydroxide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium-containing antacids can reduce oral digoxin absorption, and low magnesium increases the risk of digoxin toxicity. Digoxin itself does not meaningfully lower magnesium levels.
What this interaction means in plain words
Digoxin and Magnesium hydroxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Magnesium hydroxide belongs to Gastrointestinal Tract.
Why it happens
Magnesium hydroxide adsorbs digoxin in the gut, reducing its absorption.
What to do
Separate doses by at least 2 hours and monitor digoxin levels and heart rate if the antacid is used regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Magnesium hydroxide
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Magnesium hydroxide?
MediHelp rates the interaction as moderate. Digoxin and Magnesium hydroxide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium-containing antacids can reduce oral digoxin absorption, and low magnesium increases the risk of digoxin toxicity. Digoxin itself does not meaningfully lower magnesium levels.
How serious is the interaction between Digoxin and Magnesium hydroxide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate doses by at least 2 hours and monitor digoxin levels and heart rate if the antacid is used regularly.
What other medicines interact with Magnesium hydroxide?
MediHelp also lists interactions of Magnesium hydroxide with, for example, Ciprofloxacin, Dolutegravir, Gemifloxacin. The full list is on the Magnesium hydroxide page.
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