Drug interactions
Digoxin + Magnesium oxide
Severity: Minor
Digoxin and Magnesium oxide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Digoxin can modestly increase urinary magnesium loss, and hypomagnesemia raises digoxin toxicity risk. Oral magnesium oxide may also slightly reduce digoxin absorption if taken together.
What this interaction means in plain words
Digoxin and Magnesium oxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Magnesium oxide belongs to Gastrointestinal Tract.
Why it happens
Digoxin may increase renal magnesium excretion, and magnesium salts may bind digoxin in the gut.
What to do
Separate doses by about 2 hours and monitor serum magnesium during long-term digoxin therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Magnesium oxide
- Chloroquine + Magnesium oxide Moderate
- Ciprofloxacin + Magnesium oxide Moderate
- Dolutegravir + Magnesium oxide Moderate
- Doxycycline + Magnesium oxide Moderate
- Eltrombopag + Magnesium oxide Moderate
- Gemifloxacin + Magnesium oxide Moderate
Frequently asked questions
Can I take Digoxin with Magnesium oxide?
MediHelp rates the interaction as minor. Digoxin and Magnesium oxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Digoxin can modestly increase urinary magnesium loss, and hypomagnesemia raises digoxin toxicity risk. Oral magnesium oxide may also slightly reduce digoxin absorption if taken together.
How serious is the interaction between Digoxin and Magnesium oxide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate doses by about 2 hours and monitor serum magnesium during long-term digoxin therapy.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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