Drug interactions
Digoxin + Memantine
Severity: Minor
Digoxin and Memantine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Memantine is eliminated partly by renal tubular secretion via cationic transport, but no clinically important interaction with digoxin has been established. The competition is theoretical.
What this interaction means in plain words
Digoxin and Memantine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Memantine belongs to Central Nervous System.
Why it happens
Theoretical competition for renal tubular secretion; not shown to be clinically significant.
What to do
No dose adjustment is required; monitor for memantine adverse effects or digoxin toxicity in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Memantine
- Ketamine + Memantine Major
- Acetazolamide + Memantine Moderate
- Aluminum hydroxide + Memantine Moderate
- Amantadine + Memantine Moderate
- Dextromethorphan + Memantine Moderate
- Dofetilide + Memantine Moderate
Frequently asked questions
Can I take Digoxin with Memantine?
MediHelp rates the interaction as minor. Digoxin and Memantine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Memantine is eliminated partly by renal tubular secretion via cationic transport, but no clinically important interaction with digoxin has been established. The competition is theoretical.
How serious is the interaction between Digoxin and Memantine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required; monitor for memantine adverse effects or digoxin toxicity in patients with renal impairment.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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