Drug interactions
Digoxin + Metoprolol
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Additive AV nodal conduction slowing and negative chronotropy may increase risk of bradycardia and AV block.
Mechanism of action
Pharmacodynamic: Beta-1 blockade (metoprolol) plus increased vagal tone/AV nodal depression (digoxin) produce additive effects on AV node.
Clinical management
Use together with caution; obtain baseline and follow-up heart rate/ECG; adjust doses as needed; hold or reduce one agent if symptomatic bradycardia or PR prolongation/AV block occurs.
Drug reference
References
- Digoxin (Lanoxin) Prescribing Information — FDA Label
- Digoxin: Drug Interactions and Adverse Effects — Lexicomp
- Control of ventricular rate in atrial fibrillation: Pharmacologic therapy — UpToDate
Frequently asked questions
Can I take Digoxin with Metoprolol?
The interaction is rated: Moderate. Additive AV nodal conduction slowing and negative chronotropy may increase risk of bradycardia and AV block.
How serious is the interaction between Digoxin and Metoprolol?
The interaction is rated: Moderate. Evidence level: High.
How is the interaction between Digoxin and Metoprolol managed?
Use together with caution; obtain baseline and follow-up heart rate/ECG; adjust doses as needed; hold or reduce one agent if symptomatic bradycardia or PR prolongation/AV block occurs.
Why do Digoxin and Metoprolol interact?
Pharmacodynamic: Beta-1 blockade (metoprolol) plus increased vagal tone/AV nodal depression (digoxin) produce additive effects on AV node.
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