Drug interactions
Digoxin + Moxifloxacin
Severity: Minor
Digoxin and Moxifloxacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics may in some patients raise digoxin levels by reducing gut bacteria that metabolize it, but this is mainly described for macrolides and tetracyclines. For moxifloxacin the effect is poorly documented and probably small.
What this interaction means in plain words
Digoxin and Moxifloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Digoxin belongs to Cardiovascular; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Possible reduced intestinal bacterial inactivation of digoxin, increasing absorption; not well established for moxifloxacin.
What to do
Watch for signs of digoxin toxicity such as nausea, visual changes or arrhythmia and check digoxin levels if suspected. Check electrolytes, since arrhythmia risk is higher with low potassium.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Moxifloxacin?
MediHelp rates the interaction as minor. Digoxin and Moxifloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics may in some patients raise digoxin levels by reducing gut bacteria that metabolize it, but this is mainly described for macrolides and tetracyclines. For moxifloxacin the effect is poorly documented and probably small.
How serious is the interaction between Digoxin and Moxifloxacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for signs of digoxin toxicity such as nausea, visual changes or arrhythmia and check digoxin levels if suspected. Check electrolytes, since arrhythmia risk is higher with low potassium.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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