Drug interactions
Digoxin + Nabumetone
Severity: Moderate
Digoxin and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce renal function and may raise serum digoxin concentrations, increasing the risk of digoxin toxicity, particularly in patients with renal impairment or heart failure. Electrolyte disturbances can add to the risk.
What this interaction means in plain words
Digoxin and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Nabumetone belongs to Musculoskeletal.
Why it happens
NSAID-induced reduction in renal prostaglandin-dependent perfusion decreases digoxin renal clearance.
What to do
Monitor serum digoxin concentration, renal function and potassium when starting or stopping nabumetone. Reduce the digoxin dose if levels rise or toxicity symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Nabumetone?
MediHelp rates the interaction as moderate. Digoxin and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce renal function and may raise serum digoxin concentrations, increasing the risk of digoxin toxicity, particularly in patients with renal impairment or heart failure. Electrolyte disturbances can add to the risk.
How serious is the interaction between Digoxin and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin concentration, renal function and potassium when starting or stopping nabumetone. Reduce the digoxin dose if levels rise or toxicity symptoms appear.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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