Drug interactions
Digoxin + Osimertinib
Severity: Moderate
Digoxin and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib may inhibit P-glycoprotein and raise digoxin concentrations. Digoxin has a narrow therapeutic index, so higher levels could cause toxicity such as arrhythmias, nausea and visual disturbance.
What this interaction means in plain words
Digoxin and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Osimertinib belongs to Oncology.
Why it happens
Osimertinib inhibits P-glycoprotein, reducing digoxin efflux and renal and intestinal clearance.
What to do
Monitor digoxin serum concentrations and ECG after starting osimertinib. Reduce the digoxin dose if levels rise or signs of toxicity appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Osimertinib
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Osimertinib?
MediHelp rates the interaction as moderate. Digoxin and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osimertinib may inhibit P-glycoprotein and raise digoxin concentrations. Digoxin has a narrow therapeutic index, so higher levels could cause toxicity such as arrhythmias, nausea and visual disturbance.
How serious is the interaction between Digoxin and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin serum concentrations and ECG after starting osimertinib. Reduce the digoxin dose if levels rise or signs of toxicity appear.
What other medicines interact with Osimertinib?
MediHelp also lists interactions of Osimertinib with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Osimertinib page.
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