Drug interactions
Digoxin + Tacrolimus
Severity: Moderate
Digoxin and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus may raise digoxin levels, and both drugs can affect renal function and potassium. Cases of digoxin toxicity have been reported in transplant patients.
What this interaction means in plain words
Digoxin and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Tacrolimus belongs to Miscellaneous.
Why it happens
Tacrolimus may inhibit P-glycoprotein, reducing digoxin clearance; tacrolimus-related nephrotoxicity and electrolyte disturbance can add to the effect.
What to do
Monitor digoxin concentrations, renal function and potassium and magnesium levels. Lower the digoxin dose if levels or toxicity signs increase.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Digoxin with Tacrolimus?
MediHelp rates the interaction as moderate. Digoxin and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus may raise digoxin levels, and both drugs can affect renal function and potassium. Cases of digoxin toxicity have been reported in transplant patients.
How serious is the interaction between Digoxin and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin concentrations, renal function and potassium and magnesium levels. Lower the digoxin dose if levels or toxicity signs increase.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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