Drug interactions
Digoxin + Tolebrutinib
Severity: Moderate
Digoxin and Tolebrutinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolebrutinib may raise exposure to digoxin, which has a narrow therapeutic index. This could increase the risk of digoxin toxicity such as arrhythmia and gastrointestinal effects.
What this interaction means in plain words
Digoxin and Tolebrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Tolebrutinib belongs to Central Nervous System.
Why it happens
Inhibition of intestinal efflux transporters (P-glycoprotein) increases digoxin absorption and exposure.
What to do
Monitor serum digoxin concentrations and clinical signs of toxicity, and reduce the digoxin dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolebrutinib
Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Digoxin with Tolebrutinib?
MediHelp rates the interaction as moderate. Digoxin and Tolebrutinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolebrutinib may raise exposure to digoxin, which has a narrow therapeutic index. This could increase the risk of digoxin toxicity such as arrhythmia and gastrointestinal effects.
How serious is the interaction between Digoxin and Tolebrutinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum digoxin concentrations and clinical signs of toxicity, and reduce the digoxin dose if needed.
What other medicines interact with Tolebrutinib?
MediHelp also lists interactions of Tolebrutinib with, for example, Carbamazepine, Deferasirox, Efavirenz. The full list is on the Tolebrutinib page.
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