Drug interactions
Digoxin + Trofinetide
Severity: Moderate
Digoxin and Trofinetide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trofinetide inhibits OATP1B1/1B3 in vitro and may increase exposure to substrates of these transporters. Digoxin is only a minor OATP substrate, so the clinical effect is uncertain, but toxicity is a concern given its narrow therapeutic index.
What this interaction means in plain words
Digoxin and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Trofinetide belongs to Central Nervous System.
Why it happens
Possible inhibition of OATP-mediated hepatic uptake of digoxin by trofinetide.
What to do
Monitor digoxin concentrations and ECG after starting trofinetide. Reduce the digoxin dose if levels rise or toxicity signs appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Trofinetide
Frequently asked questions
Can I take Digoxin with Trofinetide?
MediHelp rates the interaction as moderate. Digoxin and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trofinetide inhibits OATP1B1/1B3 in vitro and may increase exposure to substrates of these transporters. Digoxin is only a minor OATP substrate, so the clinical effect is uncertain, but toxicity is a concern given its narrow therapeutic index.
How serious is the interaction between Digoxin and Trofinetide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor digoxin concentrations and ECG after starting trofinetide. Reduce the digoxin dose if levels rise or toxicity signs appear.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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