Drug interactions
Digoxin + Vemurafenib
Severity: Moderate
Digoxin and Vemurafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib can increase digoxin exposure, as shown in a pharmacokinetic study with P-glycoprotein substrates. Higher digoxin levels may lead to arrhythmias and gastrointestinal or visual toxicity.
What this interaction means in plain words
Digoxin and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Digoxin belongs to Cardiovascular; Vemurafenib belongs to Oncology.
Why it happens
Vemurafenib inhibits P-glycoprotein, decreasing digoxin efflux and elimination.
What to do
Use caution and monitor serum digoxin concentrations and ECG when starting or stopping vemurafenib. Reduce the digoxin dose if levels are elevated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Other interactions of Vemurafenib
Frequently asked questions
Can I take Digoxin with Vemurafenib?
MediHelp rates the interaction as moderate. Digoxin and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vemurafenib can increase digoxin exposure, as shown in a pharmacokinetic study with P-glycoprotein substrates. Higher digoxin levels may lead to arrhythmias and gastrointestinal or visual toxicity.
How serious is the interaction between Digoxin and Vemurafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use caution and monitor serum digoxin concentrations and ECG when starting or stopping vemurafenib. Reduce the digoxin dose if levels are elevated.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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